In 1980, he moved to the Frankfurt club Vogue, later internationally known as Omen, which became recognized as a birthplace of techno. From 1982, Brenner took over from Michael Münzing as the resident DJ at Dorian Gray at Frankfurt Airport, a position he held until Sven Väth replaced him in 1987. From 1993 to 1998, he performed at Paramount Park in Rödermark, near Frankfurt am Main.

Starting in 1994, Ulli Brenner became part of the resident team for the Hessischer Rundfunk Club Nights, Germany's most renowned techno/trance radio show, alongside Sven Väth, Mark Spoon, Talla 2XLC, and DJ Dag.

Brenner has been producing DJ mix records since 1984 and has received multiple gold records. Together with Amir Saraf, he produced the 1994 project La Bouche with Melanie Thornton, which became one of the most successful European productions of the time—reaching number one in Germany and number five in the USA—and earned him seven platinum and eleven gold records. He also produced a variety of tracks under his own label, Edition Beam/Warner Chappell Music.